|
Symbol Name ID |
Trp53
transformation related protein 53 MGI:98834 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Anorexia |
Plexiform neurofibroma |
Choroid plexus papilloma |
Astrocytoma |
Pleomorphic xanthoastrocytoma |
Ependymoma |
Glioblastoma multiforme |
Oligodendroglioma |
Choroid plexus carcinoma |
Hydrocephalus |
Agenesis of corpus callosum |
Spinal cord compression |
Gray matter heterotopia |
Neoplasm of the central nervous system |
Medulloblastoma |
Neuroblastoma |
Ataxia |
Postural tremor |
Irritability |
Polyphagia |
Hyperactivity |
Hyperreflexia |
Dystonia |
Headache |
Polyneuropathy |
Seizure |
Paresthesia |
| Disease(s) Associated with TP53 | |||||||||||||||||||||||||||
| choroid plexus papilloma | |||||||||||||||||||||||||||
| Graves' disease | |||||||||||||||||||||||||||
| Leber hereditary optic neuropathy | |||||||||||||||||||||||||||
| Li-Fraumeni syndrome | |||||||||||||||||||||||||||
| mismatch repair cancer syndrome | |||||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | nervous system phenotype |
seizures |
decreased neuron apoptosis |
abnormal neuron differentiation |
abnormal neural tube closure |
increased medulloblastoma incidence |
increased brain tumor incidence |
increased glioma incidence |
increased astrocytoma incidence |
abnormal cerebellar foliation |
decreased brain size |
increased brain size |
abnormal cerebellar cortex morphology |
abnormal cerebellar Purkinje cell layer |
thin cerebellar granule layer |
absent cerebellum vermis |
cerebellum hypoplasia |
exencephaly |
decreased neuronal precursor cell number |
abnormal optic nerve morphology |
absent optic nerve |
optic nerve degeneration |
optic nerve hypoplasia |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||
| Trp53tm1.1Manf/Trp53tm1.1Manf | ||||||||||||||||||||||||
| Trp53tm1.1Tldo/Trp53tm1.1Tldo | ||||||||||||||||||||||||
| Trp53tm1.2Awbr/Trp53tm1.2Awbr | ||||||||||||||||||||||||
| Trp53tm1Brd/Trp53tm1Brd | ||||||||||||||||||||||||
| Trp53tm1Tyj/Trp53tm1Tyj | ! | ! | ! | |||||||||||||||||||||
| Trp53tm2.1Snj/Trp53tm2.1Snj | ||||||||||||||||||||||||
| Trp53Bbl/Trp53+ | ||||||||||||||||||||||||
| Trp53bhy/Trp53+ | ||||||||||||||||||||||||
| Trp53tm1Brd/Trp53+ | ||||||||||||||||||||||||
| Trp53tm1Brd/Trp53tm8Xu | ||||||||||||||||||||||||
| Trp53tm1Brn/Trp53tm1Brn Tg(GFAP-cre)25Mes/0 (conditional) |
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| Trp53tm1Brn/Trp53tm1Brn Tg(Nes-cre/ERT2,-ALPP)1Sbk/0 (conditional) |
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| Trp53tm1Elee/Trp53tm1Elee Tg(GFAP-cre)25Mes/0 (conditional) |
* | |||||||||||||||||||||||
| Trp53tm1Brn/Trp53tm1Tyj Tg(Nes-cre)1Kln/0 (conditional) |
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| Trp53tm1Elee/Trp53tm1Tyj Tg(GFAP-cre)25Mes/0 (conditional) |
* | |||||||||||||||||||||||
| Tg(CMV-cre)1Cgn/0 Trp53tm4Att/Trp53+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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